• Over 120 Publications

  • A Journey from Invention to Innovation

  • Bone Tissue Properties Measurement by RPI


Active Life Scientific, Inc. develops medical devices and laboratory equipment for physicians and researchers who desire to directly measure bone quality in the clinic, tissues, and biomaterials.


BioDent™ is a versatile (in vivo / ex vivo – large / small samples) bench-top instrument for measuring the material properties of hard and soft tissues as well as biomaterials.

OsteoProbe® is a hand-held medical device (for research use only in the United States) utilized by physicians and clinical researchers for measuring bone material quality in vivo.


How do BioDent™ and Osteoprobe® work?

BioDent™ and OsteoProbe® use Reference Point Indentation (RPI) to investigate the material properties of a tissue. Learn more about how BioDent™ and Osteoprobe® work.

What is Reference Point Indentation?

A novel technique for measuring the local mechanical properties of a material. It sets a localized reference point at the material’s surface that enables precise indentation measurements in previously impossible environments, such as: non-uniform surfaces and in vivo. Read more about the story behind RPI.


Citations Graph

Reference Point Indentation has been cited over 1000 times since its invention. It is an established measure of bone material quality.


Over 40 BioDents™ are currently being used on five continents by leading institutions!
Since its invention, over   120   publications have been accepted into peer-reviewed journals



Perhaps the closest clinical [research] measurement of bone's resistance to crack propagation is the indentation distance increase (IDI) that is quantified using Reference Point Indentation (RPI).

- Nyman, J.S.; Makowski, A. J. (Current Osteoporos Report 2012)


Customers, Collaborators, and Funding Sources